APPLYING MACHINE LEARNING TO A-T

With an undergraduate degree in electrical engineering, medical training in neurology, and a PhD in robotics, Anoopum Gupta, MD, PhD at Massachusetts General Hospital is unusually qualified to apply new technologies to unravel complicated neurological problems like A-T. Supported by the A-T Children’s Project, Dr. Gupta has begun training a computer system to analyze video, … Read More

A-T FAMILIES PROVIDING DATA TO RESEARCHERS

A year has passed since the launch of the Global A-T Family Data Platform, an effort overseen by A-T families to enable researchers and clinicians to mine large data sets and gain new insights about ataxia-telangiectasia. So far, A-T families from 19 countries have contributed health information about their children who have A-T. The platform’s … Read More

Targeting Neutrophil-driven Inflammation to Reduce Lung Problems in A-T

The A-T Children’s Project has begun exploring whether anti-inflammatory drugs might prevent or reduce lung problems that can become life-threatening for people with ataxia-telangiectasia. The organization has awarded funding to JoAnn Sekiguchi, PhD at the University of Michigan to determine if anti-inflammatory compounds can reduce lung damage in a mouse model of A-T. About 25 … Read More

A-T IN LATIN AMERICA

The A-T Children’s Project is funding Beatriz Tavares Costa-Carvalho, MD and her colleagues to learn more about A-T in the Latin American population with a new grant entitled Ataxia-Telangiectasia: Epidemiological Survey in Latin America. Studying how a disease affects people over time is important not just to understanding the nature of the disease and its … Read More

INFLAMMATION, SWALLOWING, AND AGING IN A-T

Sharon McGrath-Morrow, a pediatric pulmonologist, published results showing that higher levels of IL-6 and IL-8 in the blood, markers for inflammation, are associated with poorer lung function in people with A-T, suggesting a link between inflammation and lung decline in this disease. Maureen Lefton-Greif, a speech and swallowing specialist, published results demonstrating abnormal coupling of … Read More

A-T CLINICAL EXPERTS MEET IN POLAND

From October 6-8, clinicians, therapists and scientists gathered in Warsaw, Poland for the 2016 A-T Clinical Research Conference to discuss ways to improve the care for individuals with A-T. Highlights from the meeting included: An update on the CATNAP Study, a large pediatric neuroimaging study being performed in the UK and co-funded by the A-T … Read More

EXAMINING LUNG BACTERIA IN A-T

Because more than 25% of patients with ataxia-telangiectasia (A-T) develop some form of chronic lung disease, the A-T Children’s Project has awarded a fellowship grant to Abrey Yeo, PhD in Australia to examine the mixture of bacteria found in the airways of individuals with A-T. Even healthy people have numerous types of bacteria in their … Read More

LONG TIME ADVISORS ELECTED TO THE NATIONAL ACADEMY OF SCIENCES

Two of our long time scientific advisors have been elected to the prestigious National Academy of Sciences, one of the highest honors bestowed upon research scientists. Nathaniel Heintz, PhD Nathaniel (Nat) Heintz is the James and Marilyn Simons Professor and head of the Laboratory of Molecular Biology at The Rockefeller University in New York. Dr. … Read More

TESTING DRUGS TO PROTECT A-T BRAIN CELLS FROM DNA DAMAGE

Many drugs now taken by millions of people were discovered by high-throughput drug screening, a process in which scientists use robotics, data processing and control software, liquid handling devices and sensitive detectors to quickly perform millions of chemical tests until they find compounds that correct a biomolecular pathway that scientists believe is relevant to a … Read More

FAMILIES OF ATAXIA-TELANGIECTASIA PATIENTS WORLDWIDE LAUNCH NEW DATA PLATFORM TO EMPOWER RESEARCHERS

Families will contribute their data using on-line family questionnaires, whole-genome sequencing and other approaches, serving as a model for other diseases Families around the world who have children affected by ataxia-telangiectasia (A-T) today announced the launch of the Global A-T Family Data Platform, through which health, genomic and potentially other types of data about their … Read More