EXPANDING MRI IMAGING FOR A-T BEYOND THE BRAIN TO LUNGS

Recently, Stephen Rose, Kate Sinclair and Martin Lavin from the Queensland Institute of Medical Research in Brisbane, Australia, successfully used a special kind of magnetic resonance imaging (MRI), called diffusion MRI, to examine the brains of people with A-T at various ages. They observed changes in the cerebellum and in projections from the cerebellum to … Read More

SPINAL FLUID MAY HOLD CLUES FOR A-T

With funding from the A-T Children’s Project, Stefan Zielen and Ralf Schubert from the Goethe University in Frankfurt, Germany will examine spinal fluid from children and adolescents with A-T in an attempt to identify measurable indicators of oxidative stress, inflammation, or tissue breakdown that correlate with disease progression and severity. Spinal fluid, the clear fluid … Read More

RECURSION PHARMACEUTICALS ANNOUNCES FUNDING SUPPORT FOR ATAXIA-TELANGIECTASIA

Press Release from Recursion Pharmaceuticals Salt Lake City – Recursion Pharmaceuticals, an emerging biotech company today announced receipt of a research award from the A-T Children’s Project, which seeks to support research for the disease ataxia-telangiectasia. Ataxia-telangiectasia (A-T) is a rare genetic disease that attacks children, causing progressive loss of muscle control, immune system problems, … Read More

MD-PHD STUDENT FOCUSES ON EYE PROBLEMS IN A-T

Pavan Vaswani, an MD-PhD student at the Johns Hopkins University School of Medicine, has just earned the PhD portion of his dual degree by researching eye movements in A-T. In the Laboratory for Computational Motor Control, headed by Reza Shadmehr, PhD, and under the guidance of Thomas Crawford, MD, pediatric neurologist for the A-T Clinical … Read More

WHEN PARENTS START COMPANIES TO CURE THEIR CHILDREN

For These CEOs, Helping Ill Offspring Can Mean Putting Profits First By AMY DOCKSER MARCUS – December 26, 2014 – Wall Street Journal For years, Brad Margus has juggled two goals as chief executive: Make money, and find cures for his children. He just co-founded a startup, Exigence Neurosciences Inc., in part to seek treatments … Read More

MITOCHONDRIA EXPERTS PONDER A-T

Mitochondria, tiny oval structures found within our cells, are essentially power houses. They produce the energy our cells need to function and survive. And abnormal mitochondrial activity plays a role in many diseases, including several neurological disorders. Recently, several research teams working on A-T have produced data hinting that mitochondrial activity – including the production … Read More

HOW DOES A-T AFFECT LEARNING AND EMOTIONS?

Instead of studying the movement problems of A-T, neuroscientists at Massachusetts General Hospital and Harvard Medical School will soon begin studying how A-T affects cognition, especially how A-T kids learn and process emotions. Besides increasing our understanding of the abnormal brain circuitry in A-T, this study may produce recommendations that help children with A-T do … Read More

A-T BRAIN IMAGING STUDY OFFERS CLUES FOR TREATMENTS

In a groundbreaking imaging study just published in the journal Brain, researchers made unexpected discoveries about brain activity that now have them thinking about new treatments that could help people with ataxia-telangiectasia (A-T) control their movements better. Nora Volkow, MD, Director of the National Institute on Drug Abuse at the National Institutes of Health, spearheaded the … Read More