With funding from the A-T Children’s Project, the laboratory of Anthony Wynshaw-Boris, MD, PhD at Case Western Reserve University in Cleveland, Ohio will attempt to grow A-T brain cells in laboratory dishes to overcome the obstacle of not being able to access and study living brain cells from A-T patients. Dr. Wynshaw-Boris knows A-T well. … Read More
With a multi-year grant award from the A-T Children’s Project, Yossi Shiloh, PhD from Tel Aviv University in Israel will now turn much of his laboratory’s focus toward how the loss of the A-T protein causes brain cells to die in people with A-T. Dr. Shiloh first met children with A-T when he was a … Read More
Scientists and clinicians from around the world traveled to Beijing, China in October to share information at the 2015 A-T Workshop, a meeting co-sponsored by the A-T Children’s Project and held at the Capital Normal University. Beyond primarily discussing DNA repair roles of the ATM protein as in the past, this year’s meeting included sessions … Read More
Scientists have known for a long time that skin and blood cells obtained from A-T patients do not survive as well as cells from healthy people, and recent discoveries have hinted that A-T cells, especially brain cells in A-T patients, may be dying because of defective cell metabolism. The A-T Children’s Project has therefore funded … Read More
Recently, Stephen Rose, Kate Sinclair and Martin Lavin from the Queensland Institute of Medical Research in Brisbane, Australia, successfully used a special kind of magnetic resonance imaging (MRI), called diffusion MRI, to examine the brains of people with A-T at various ages. They observed changes in the cerebellum and in projections from the cerebellum to … Read More
With funding from the A-T Children’s Project, Stefan Zielen and Ralf Schubert from the Goethe University in Frankfurt, Germany will examine spinal fluid from children and adolescents with A-T in an attempt to identify measurable indicators of oxidative stress, inflammation, or tissue breakdown that correlate with disease progression and severity. Spinal fluid, the clear fluid … Read More
Press Release from Recursion Pharmaceuticals Salt Lake City – Recursion Pharmaceuticals, an emerging biotech company today announced receipt of a research award from the A-T Children’s Project, which seeks to support research for the disease ataxia-telangiectasia. Ataxia-telangiectasia (A-T) is a rare genetic disease that attacks children, causing progressive loss of muscle control, immune system problems, … Read More
MAKING SURE A NEW A-T RATING SCALE IS USED CORRECTLY WORLDWIDE February 2015 – When clinical trials are performed by researchers at different sites to test the efficacy of potential medicines in A-T patients, it is critical for all the researchers to use the same scale, accurately and consistently, to measure each patient’s condition before … Read More
Pavan Vaswani, an MD-PhD student at the Johns Hopkins University School of Medicine, has just earned the PhD portion of his dual degree by researching eye movements in A-T. In the Laboratory for Computational Motor Control, headed by Reza Shadmehr, PhD, and under the guidance of Thomas Crawford, MD, pediatric neurologist for the A-T Clinical … Read More
For These CEOs, Helping Ill Offspring Can Mean Putting Profits First By AMY DOCKSER MARCUS – December 26, 2014 – Wall Street Journal For years, Brad Margus has juggled two goals as chief executive: Make money, and find cures for his children. He just co-founded a startup, Exigence Neurosciences Inc., in part to seek treatments … Read More
