TESTING DRUGS TO PROTECT A-T BRAIN CELLS FROM DNA DAMAGE

Many drugs now taken by millions of people were discovered by high-throughput drug screening, a process in which scientists use robotics, data processing and control software, liquid handling devices and sensitive detectors to quickly perform millions of chemical tests until they find compounds that correct a biomolecular pathway that scientists believe is relevant to a … Read More

FAMILIES OF ATAXIA-TELANGIECTASIA PATIENTS WORLDWIDE LAUNCH NEW DATA PLATFORM TO EMPOWER RESEARCHERS

Families will contribute their data using on-line family questionnaires, whole-genome sequencing and other approaches, serving as a model for other diseases Families around the world who have children affected by ataxia-telangiectasia (A-T) today announced the launch of the Global A-T Family Data Platform, through which health, genomic and potentially other types of data about their … Read More

GROWING A-T BRAIN CELLS IN A DISH

With funding from the A-T Children’s Project, the laboratory of Anthony Wynshaw-Boris, MD, PhD at Case Western Reserve University in Cleveland, Ohio will attempt to grow A-T brain cells in laboratory dishes to overcome the obstacle of not being able to access and study living brain cells from A-T patients. Dr. Wynshaw-Boris knows A-T well. … Read More

CAREER A-T RESEARCHER FOCUSES ON BRAIN

With a multi-year grant award from the A-T Children’s Project, Yossi Shiloh, PhD from Tel Aviv University in Israel will now turn much of his laboratory’s focus toward how the loss of the A-T protein causes brain cells to die in people with A-T. Dr. Shiloh first met children with A-T when he was a … Read More

ATW2015 INCLUDES SESSIONS ON NEUROGENERATION AND NON-TRADITIONAL ROLES OF THE A-T PROTEIN

Scientists and clinicians from around the world traveled to Beijing, China in October to share information at the 2015 A-T Workshop, a meeting co-sponsored by the A-T Children’s Project and held at the Capital Normal University. Beyond primarily discussing DNA repair roles of the ATM protein as in the past, this year’s meeting included sessions … Read More

CORRECTING CELL METABOLISM IN A-T

Scientists have known for a long time that skin and blood cells obtained from A-T patients do not survive as well as cells from healthy people, and recent discoveries have hinted that A-T cells, especially brain cells in A-T patients, may be dying because of defective cell metabolism. The A-T Children’s Project has therefore funded … Read More

EXPANDING MRI IMAGING FOR A-T BEYOND THE BRAIN TO LUNGS

Recently, Stephen Rose, Kate Sinclair and Martin Lavin from the Queensland Institute of Medical Research in Brisbane, Australia, successfully used a special kind of magnetic resonance imaging (MRI), called diffusion MRI, to examine the brains of people with A-T at various ages. They observed changes in the cerebellum and in projections from the cerebellum to … Read More

SPINAL FLUID MAY HOLD CLUES FOR A-T

With funding from the A-T Children’s Project, Stefan Zielen and Ralf Schubert from the Goethe University in Frankfurt, Germany will examine spinal fluid from children and adolescents with A-T in an attempt to identify measurable indicators of oxidative stress, inflammation, or tissue breakdown that correlate with disease progression and severity. Spinal fluid, the clear fluid … Read More

RECURSION PHARMACEUTICALS ANNOUNCES FUNDING SUPPORT FOR ATAXIA-TELANGIECTASIA

Press Release from Recursion Pharmaceuticals Salt Lake City – Recursion Pharmaceuticals, an emerging biotech company today announced receipt of a research award from the A-T Children’s Project, which seeks to support research for the disease ataxia-telangiectasia. Ataxia-telangiectasia (A-T) is a rare genetic disease that attacks children, causing progressive loss of muscle control, immune system problems, … Read More