With funding from the A-T Children’s Project, Stefan Zielen and Ralf Schubert from the Goethe University in Frankfurt, Germany will examine spinal fluid from children and adolescents with A-T in an attempt to identify measurable indicators of oxidative stress, inflammation, or tissue breakdown that correlate with disease progression and severity. Spinal fluid, the clear fluid … Read More
Press Release from Recursion Pharmaceuticals Salt Lake City – Recursion Pharmaceuticals, an emerging biotech company today announced receipt of a research award from the A-T Children’s Project, which seeks to support research for the disease ataxia-telangiectasia. Ataxia-telangiectasia (A-T) is a rare genetic disease that attacks children, causing progressive loss of muscle control, immune system problems, … Read More
MAKING SURE A NEW A-T RATING SCALE IS USED CORRECTLY WORLDWIDE February 2015 – When clinical trials are performed by researchers at different sites to test the efficacy of potential medicines in A-T patients, it is critical for all the researchers to use the same scale, accurately and consistently, to measure each patient’s condition before … Read More
Pavan Vaswani, an MD-PhD student at the Johns Hopkins University School of Medicine, has just earned the PhD portion of his dual degree by researching eye movements in A-T. In the Laboratory for Computational Motor Control, headed by Reza Shadmehr, PhD, and under the guidance of Thomas Crawford, MD, pediatric neurologist for the A-T Clinical … Read More
For These CEOs, Helping Ill Offspring Can Mean Putting Profits First By AMY DOCKSER MARCUS – December 26, 2014 – Wall Street Journal For years, Brad Margus has juggled two goals as chief executive: Make money, and find cures for his children. He just co-founded a startup, Exigence Neurosciences Inc., in part to seek treatments … Read More
Mitochondria, tiny oval structures found within our cells, are essentially power houses. They produce the energy our cells need to function and survive. And abnormal mitochondrial activity plays a role in many diseases, including several neurological disorders. Recently, several research teams working on A-T have produced data hinting that mitochondrial activity – including the production … Read More
Scientists led by Michael Kastan, MD, PhD, head of the Duke Cancer Institute in Durham, North Carolina, have discovered that cells taken from A-T children are abnormally sensitive when deprived of nutrients such as glucose, glutamine and oxygen. With a grant from the A-T Children’s Project, the team will now study metabolic stress pathways in … Read More
Instead of studying the movement problems of A-T, neuroscientists at Massachusetts General Hospital and Harvard Medical School will soon begin studying how A-T affects cognition, especially how A-T kids learn and process emotions. Besides increasing our understanding of the abnormal brain circuitry in A-T, this study may produce recommendations that help children with A-T do … Read More
In a groundbreaking imaging study just published in the journal Brain, researchers made unexpected discoveries about brain activity that now have them thinking about new treatments that could help people with ataxia-telangiectasia (A-T) control their movements better. Nora Volkow, MD, Director of the National Institute on Drug Abuse at the National Institutes of Health, spearheaded the … Read More
From the Sanford-Burnham Medical Research Institute Press Release: Researchers discover mutations in a protein that plays a role in the body’s DNA repair system—similar to what’s observed in the rare children’s disease ataxia-telangiectasia. The discovery provides an approach to identifying therapies that will resuscitate the broken DNA repair mechanism. Newswise — LA JOLLA, Calif., March … Read More
