With funding from the A-T Children’s Project and the Australian-based BrAshA-T organization, a team of researchers in Australia is using neuroimaging technology to learn more about abnormal circuitry and inflammation in the brains of A-T patients, possibly providing clues for therapeutic targets and uncovering imaging biomarkers for use in clinical trials. Stephen Rose, PhD, Kate … Read More
The A-T Children’s Project welcomes Dr. Philip LoGrasso to its Scientific Advisory Board. Dr. LoGrasso is a Professor in the Molecular Therapeutics Department and Senior Director of Drug Discovery in the Translational Research Institute within The Scripps Research Institute where he has been since 2005. He current serves on the Scientific Advisory Board for Envoy … Read More
With help from scientists who specialize in brain imaging, the A-T Children’s Project is seeking ways to treat the abnormal brain circuitry in ataxia-telangiectasia (A-T). For the first time, a comprehensive PET and fMRI study of the brains of adults with A-T has begun. PET stands for Positron Emission Tomography, and these scans give three … Read More
Three papers have been published recently in the scientific literature describing: 1) gastrostomy tube (G-tube) safety and satisfaction in patients with A-T; 2) the care of critically ill A-T patients and 3) the care of patients with A-T undergoing operations and the possible risks associated with the use of anesthesia for surgical procedures. G-Tube Placement … Read More
The A-T Children’s Project has granted funding for Yang Xu, PhD from the University of California, San Diego to continue development of a stem cell-based model for A-T. This type of “disease-in-a-dish” model can be used to screen hundreds of thousands of compounds for their ability to diminish or reverse certain characteristics of the disease … Read More
Benjamin Siddoway, PhD from the Louisiana State University (LSU) Health Sciences Center is the first recipient of the A-T Children’s Project’s Post Doctoral Fellowship Award for his grant entitled “Addressing neurological dysfunction in A-T: Investigation into novel, physiologic ATM activation in neurons and ATM-PP1 signaling in reorganization and refinement of post synaptic architecture.” The A-T … Read More
The A-T Children’s Project is funding two new research grants that may provide insights regarding brain function in A-T. The Florida-based Wobbly Feet Foundation has agreed to co-fund part of each grant in an on-going partnership to accelerate A-T research. Research for the first grant, entitled “Linking neurodegeneration to protein turnover in ataxia-telangiectasia,” will be … Read More
The A-T Children’s Project and the A-T Society in the United Kingdom have jointly awarded a grant to Emma Ross PhD, from the University of Brighton in England, entitled “Inspiratory muscle training in patients with Ataxia-Telangiectasia.” Lung disease is a frequent and often serious problem in patients with A-T. A 2010 paper in the journal … Read More
Lung problems cause sickness and death in many patients with ataxia-telangiectasia (A-T). However, a lack of information from following A-T patients’ lung disease over time has limited doctors’ knowledge of these critical problems. With the goal of providing expert advice on the diagnosis, evaluation, and management of lung disease in A-T, Dr. Sharon McGrath- Morrow … Read More
Since the late 1990s, Paul K.Y. Wong, PhD, from the University of Texas MD Anderson Cancer Center has been exploring what goes wrong in blood and brain cells when the A-T protein is missing. Although A-T is not the primary research focus for Dr. Wong, a leading investigator in the area of mouse retroviruses as … Read More
