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New Publication on Inflammation and A-T

Sharon McGrath-Morrow, MD, a pediatric pulmonologist with the A-T Clinical Center at Johns Hopkins Hospital, has found that levels of a pro-inflammatory molecule in the body called IL-8 are often elevated in patients with ataxia-telangiectasia (A‑T).

IL-8 is associated with premature cell aging, cancer progression and chronic inflammatory disorders. In her study, Dr. McGrath-Morrow found that IL-8 levels in patients with A-T were higher than that of patients with cystic fibrosis, non-A-T immunodeficiency, and healthy controls. These results, which have recently been accepted for publication in the Journal of Pediatrics, suggest that systemic inflammation may play a role in A-T. With further study, these findings may represent an avenue for potential therapy.


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